Ryza no Atelier follows the story of Stout Reisalin, a girl living on Kurken Island in search of adventure. She discovers an abandoned row boat one summer day and sets out to the mainland with her friends Marslink Lent and Mongarten Tao. Along the way, Ryza meets the alchemist Vollmer Empel and his companion Decyrus Lila, which sets her on the path of learning alchemy and her intertwining adventures, and she soon discovers the truth about her home.